For health-related questions, always consult your veterinarian, as they have examined your pet, know the pet's health feline anal sac irritation, and can make the best recommendations for your pet. Is this related to anal sac disease? Took Pepe to the vet bout feline anal sac irritation month ago because he had blood and looked very swollen around his anus. I hate that the only solution is taking him monthly. Each time my cat has had something wrong with her anal sacs, usually an infection. The condition may reoccur, which is why it is important to revisit your veterinarian and discuss prevention methods of anal sac disease in your cat. Chagas Disease.